Stem Cells and Hair Cloning
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Another global fraud that occurred in all countries over the last two years by famous scientists who have no connection with the subject of hair transplantation ( but act solely motivated by profit) is stem cell therapy . They manage to advertising tricks to convince stakeholders be treated with stem cells or growth factors . Injecting fat or serum autologous blood (PRP) in the area of thinning hair , taken after liposuction on various parts of the body or blood sampling, and argue that because adipose tissue and blood serum containing stem cells will be created new follicles . The absolute fraud with stakeholders to pay from 1000 to 4000 euros without seeing some results.

The truth is that the continuous and rapid progress of genetic leaves much promise for the treatment of hair los : Cloning follicular units will probably be the big step in treating baldness .

The discovery in hair follicles of embryonic stem cells that are virtually " immortal " and can differentiate into various types of tissues opened new perspectives in androgenetic alopecia .

Cloning follicular units is the process of extracting cells from the hair follicles, multiplying them laboratory and replant them in the scalp so that they continue to produce new hair growth.

Based on the investigations, the fibroblasts, located in follicular units , it is easier to reproduce in relation to other cells of the hair follicle . After extraction of follicular units from the donor area, allow researchers to separate the fibroblasts and then cultivate them in the laboratory to create new follicular units. The workshop takes place from multiplying and then placed in the thinning area of the scalp to begin developing new follicular units.

The main problem is that they have become more clinical studies on safety and effectiveness of these methods. If not applied in large series of patients and not be compared with corresponding groups taking placebo can’t know if they actually work. The reason is that each person is different so the skin and hair follicles respond differently to treatment. Mostly though as we said alopecia is genetically determined, so that we use is for maintenance of existing hair and to retard the final result. So it takes patience and perseverance, realistic expectations and optimism as the definitive solution to the efficient stimulation of stem cells, gene modification of hair follicles or cloning them maybe not so far away!

As the research process, is a purely experimental stage and presents some encouraging signs , however, still required extensive research effort.

By cloning hair abolished finite potential donor area and there will be no limitations as a safe limit for the stock of hair growth. Even the candidates for hair transplantation which is insufficient in terms of stocks donor area to undergo hair transplant, cloning hair follicles could be candidates for hair transplantation.

The main points on which the research work focuses on hair cloning are as follows:

The cell type chosen for reproduction, there are other types than fibroblasts

Ensuring effective cultivation and reproduction of cells in the laboratory

Proper placement in dilution to promote effective and desirable way to develop

Difficulties in cloning hair follicles, mainly the inability advance fixing both address germination of new hair and the density and quality of new hair growth .

The hair transplant doctor determines how outgrowth of new hair, gives hair the desired orientation to develop the appropriate address and distributes hair follicles in normal distance to ensure natural results.

By cloning hair is difficult to estimate the final result : it is not possible at present to predict the percentage of follicles that will grow or to ensure uniform density or quality standards for new hair ( in the process of reproduction , new cells undergo differentiation in the original ) .

Still, no one can guarantee that the new hair will follow the normal life cycle of the hair, or that will remain forever as hair transplantation .

And of course to mention that to get approved in the future cloning hair follicles will be absolutely secure . It is imperative to study whether the cloned follicles may lead to the creation of tumors.

Opinions differ on the exact time at which the cloning hair follicles is a widely used technique with good results for the treatment of hair loss . What is certain is that it still requires several years of research and experiment .

Once surmount these difficulties then cloning will be the final solution to the problem of hair loss as it will eliminate the restriction of the donor area since even patients with high degree of baldness ( or androgenetic or other reasons eg Burns ) can achieve full recovery with as much density wish .

The first research center which had some effect on cloning hair follicles was the company Intercytex Manchester - England led by Dr. Farjo.

The British research team supported by a government grant of 1.9 million pounds ( 2.4 million euros).

Provided export nipple hair , basic cells responsible for hair growth , from a sample of only 100 hairs in the constant -growth. Then these cells proliferate in culture before special implanted back millions , inducing the formation of new hair follicles.

The latest results of the second phase of the research were presented in Rome in 2009 at a conference of leading plastic surgeons hair transplant and showed that the technique can increase the number of hairs at least two- thirds of patients after six months.

Unfortunately, this company went bankrupt four years ago and was bought by Canadian company Aderans that continues the research work of Intercytex.

Unfortunately follicles generated by cloning only grow for a short time and then regress.

The reasons for failure are either

1 ) Genetic, since the aging process may have been accumulated in the DNA of the nucleus of the donor cell

2 ) Epigenetic , the inability reprogramming of the genome , which normally occurs during fetal development derived from two gametes ( egg and sperm ) .

Pr. George Kotsarelis, head of the department of Dermatology at the Perelman School of Medicine University of Pennsylvania , viewed from the front pages of major newspapers in March 2012 , when it published the results of his research in collaboration with Dr. Luis Garza , the basis of which responsible for loss of hair growth appears to be a prostaglandin synthetase protein D2.

Pr Kotsarelis discovered that stem cells play a role in androgenetica alopecia .

Doctor using cell samples from men undergoing hair transplants , compared follicles from bald and non - bald head , and found that bald areas containing the same number of stem cells as in the case of the sample of the scalp .

However , another more mature cell type called as progenitor cell was shown in studies to be exhausted in the follicles of bald .

The researchers hypothesized that baldness may eventually result from a problem with the activation of stem cells and not with the number of stem cells found in the pockets of the scalp .

In other words , baldness cause a problem in the activation of hair follicles , thus , while continuing to create new hair, were very weak or did not grow enough to penetrate the skin's surface .

Dr. Kotsarelis noting that there is a problem in the activation of stem cells and the conversion of progenitor cells in completely bald head, was able to isolate a specific genetic pathway that allows the hair follicles to form during treatment in exactly the same way they did in during embryonic development.

Doctor speaking officially for the results of his investigations , claimed that a protein in an abnormal amount called Prostaglandin D2 inhibits the growth of hair on the scalp and this discovery could lead directly to new genetic treatments for male pattern baldness .

In August 2012 the k.Kotsarelis announced that he is in advanced discussions with pharmaceutical companies to develop a therapy and support as possible this treatment can be prepared and released to the market sometime within the next two years.

The Greek-American researcher believes that the activation with a medication of this protein may reactivate hair follicles . " We found a target for the treatment of baldness ," says he and his research team . "The next step is to search for those substances that bind the receptor protein , to see if it could reverse the process of hair loss ."

This treatment is expected to help men who are in the early stages of hair loss , slowing the weakening of new hair . Professor Kotsarelis was the first to identify stem cells of hair follicles in 1990 , making experiments with mice . " We were able to show that when we isolate the stem cells and the implant in other mice , those put out new hair ." In coming years, focused on the problems of hair growth in male pattern baldness . His next step , according to the «New York Times», is to study and now face the problems of women who lose their hair .

The Scientific Group of VIP Hair Clinic will keep you informed at regular intervals for all the latest developments in stem cell and cloning hair follicles .